Buccaneers RB Cadillac Williams will face a non-division opponent in Week 1 at Buffalo. The Bills allowed the ninth fewest rushing yards in the league in Week 1 at New England, giving up 73 yards and one rushing touchdown.
Cardinals RB Tim Hightower, who caught a career-high 12 passes in a Week 1 win over the 49ers, will take on the Jaguars in Week 2. Jacksonville allowed seven catches for 51 yards to running backs in a Week 1 loss to the Colts.
Panthers RB Jonathan Stewart is listed as probable for Week 2 at Atlanta after being limited in practice with a lingering Achilles' injury. Stewart should play, but not start or see the lion's share of reps -- those will go to DeAngelo Williams. Figure Stewart to be no better than a low-end No. 3 running back for Week 2 against the Falcons, who he totaled 70 yards and a touchdown against last season.